Transition Metal Catalyzed Remote C-H Activation: A New Direction Towards Site-Selective Chemical Reactions

Abstract

Transition metal catalyzed remote C-H activation offers a powerful tool to modify architecture of organic molecules. Remote or distal C-H activation of aromatic and aliphatic compounds presents more challenge than proximal sites due to the inaccessibility of these sites in formation of energetically favorable organometallic pre-transition states. Nonetheless, recent years have witnessed remarkable progress in reaching out and functionalizing distal C-H bonds. With the advancement of this field, synthetic modifications of organic molecules have become more step and atom economical, and have shown great promise to revolutionize synthetic organic chemistry.