Transition metal-catalyzed reactivity of carbenes with boronic acid derivatives for arylation (alkylation) and beyond.

Abstract

This comprehensive review article discussed the reactivity of carbenes with boronic acid derivatives for the one-pot synthesis of diarylmethanes, difluoromethylated arenes, aryl and alkyl boron compounds, arylacetic acid derivatives, furan derivatives, and many other compounds. We have summarized the arylation, vinylation, and alkylation of carbenes utilizing various transition metals, viz. palladium, rhodium, copper, and platinum, for the construction of carbon-carbon bonds, carbon-boron bonds, and beyond through the cross-coupling strategy. The reason for the increasing popularity of these novel methodologies is their application in the synthesis and late-stage functionalization of biologically active compounds and natural products. Notably, organoboron compounds are exemplified as versatile synthetic intermediates for constructing various bonds.