Abstract

Non-steroidal anti-inflammatory drugs (NS AIDs) are among the most commonly-prescribed drugs in Germany, and the tendency to prescribe NSAIDs is increasing. In 1988 354,000,000 defined daily doses (DDD) of NSAIDs were prescribed in West Germany, a 6.1% increase over the 1987 figure. A great variety of NSAIDs are known (propionic acid derivatives, oxicam derivatives, arylacetic acid derivatives, nicotinic acid derivatives, acrylacetic acid derivatives, anthranilic acid derivatives, indoleacetic acid derivatives, and pyrazolone derivatives), but the market is controlled by only a few products. The most frequently-prescribed NSAID was the arylacetic acid derivative diclofenac (50% of all prescriptions), followed in descending order by indomethacin, ibuprofen, and piroxicam [1]. NSAIDs of all groups are well known for their various cutaneous side-effects [2]. The ability to cause photosensitivity (i.e. phototoxic reactions) is recognized for the phenylpropionic acid derivatives benoxaprofen, carprofen, ketoprofen, tia-profenic acid, and naproxen as well as the oxicam derivate piroxicam [3].

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