Abstract
Due to their high strain, unique bonding and relative ease of ring-cleavage, and because they are readily accessible, cyclopropanols have been employed in an increasing number of transition-metal-catalyzed C–C and C–X (X = heteroatom) bond-forming reactions. We review the recent literature and organize all the methods developed along mechanistic lines. 1 Introduction and Scope 2 C–C Bond Formation via Catalytic Generation and Coupling of Cyclopropanol-Derived Homoenolates 3 C–N Bond Formation via Catalytic Generation and Coupling of Cyclopropanol-Derived Homoenolates 4 C–C Bond Formation via Stoichiometric Generation and Coupling of Cyclopropanol-Derived Homoenolates 5 Ring Expansion of Cyclopropanols to Cyclobutanones via Transition-Metal-Catalyzed Wagner–Meerwein Shift 6 Transition-Metal-Catalyzed Rearrangement of Cyclopropanols to Cyclopentenones and Cyclohexenones 7 Synthesis of Medium-Size Rings via Multicomponent Reactions Involving Cyclopropanols 8 C–C and C–X Bond Formation via Free-Radical Fragmentation of Cyclopropanols 9 Summary and Outlook
Published Version
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