Abstract
Dengue Dengue virus genetic variation and ambient temperature influence the rate of transmission by mosquitoes and thus the risk and magnitude of an outbreak. Virus in a blood meal within the vector mosquito's gut takes several days—roughly a quarter of the short life of an Aedes mosquito—to transition from the gut to the salivary gland, ready for inoculation into the next host. So, 1 day's difference can mean success or failure for ongoing transmission. Fontaine et al. found that eight strains of recently circulating dengue virus have different gut–salivary gland transit times. In an agent-based model, this parameter translated into a roughly 20% difference in the probability of a subsequent human infection, with a Haitian strain being the slowest, resulting in smaller outbreaks. PLOS Pathog. 10.1371/journal.ppat.1007187 (2018).
Published Version
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