Abstract
The paper highlights the critical aspects in the design of high performance transimpedance amplifiers to be used for the electrical characterisation of nano-biodevices. Current sensitivity, bandwidth, dynamic range and leakage current discharge are discussed to cope the tight needs in impedance spectroscopy measurements at the nanoscale. An implementation in a standard 0.35 UPmum CMOS technology using dual power supply of ± 1.5 V is described in detail: thanks to an active resistor of equivalent value up to 300 GΩ and minimum noise, a transimpedance amplifier operating from few Hz is obtained, featuring an operative dynamic range for ac current signals independent of the amount of the leakage current and allowing an unlimited measuring time, ideal for attoFarad capacitance measurements of biological samples in their physiological medium.
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