Abstract

PurposeDiabetes mellitus is an increasingly common systemic disease. Many diabetic patients seek cataract surgery for a better visual acuity. Unlike in the general population, the influence of cataract surgery on tear film function in diabetic patients remains elusive. The aim of this study was to evaluate the tear function in diabetic and nondiabetic patients following cataract surgery.MethodsIn this prospective, interventional case series, 174 diabetic patients without dry eye syndrome (DES) and 474 age-matched nondiabetic patients as control who underwent phacoemulsification were enrolled at two different eye centers between January 2011 and January 2013. Patients were followed up at baseline and at 7 days, 1 month, and 3 months postoperatively. Ocular symptom scores (Ocular Surface Disease Index, OSDI) and tear film function including tear film stability (tear film break-up time, TBUT), corneal epithelium integrity (corneal fluorescein staining, CFS), and tear secretion (Schirmer’s I test, SIT) were evaluated.ResultsIn total, 83.9% of the diabetic patients (146 cases with 185 eyes) and 89.0% of the nondiabetic patients (422 cases with 463 eyes) completed all check-ups after the interventions (P = 0.095). The incidence of DES was 17.1% in the diabetic patients and 8.1% in the nondiabetic patients at 7 days after cataract surgery. In the diabetic patients, the incidence of DES remained 4.8% at 1 month postoperatively and decreased to zero at 3 months after surgery. No DES was diagnosed in nondiabetic patients at either the 1-month or 3-month follow-up. Compared with the baseline, the diabetic patients had worse symptom scores and lower TBUT values at 7 days and 1 month but not at 3 months postoperatively. In the nondiabetic patients, symptom scores and TBUT values had returned to preoperative levels at 1-month check-up. CFS scores and SIT values did not change significantly postoperatively in either group (P = 0.916 and P = 0.964, respectively).ConclusionsDiabetic patients undergoing cataract surgery are prone to DES. Ocular symptoms and tear film stability are transiently worsened in diabetic patients and are restored more slowly than those in nondiabetic patients.

Highlights

  • As one of the most successful surgical interventions, cataract surgery involves removing the opaque lens of the eye and replacing it with an artificial lens

  • No dry eye syndrome (DES) was diagnosed in nondiabetic patients at either the 1-month or 3-month follow-up

  • Diabetic patients undergoing cataract surgery are prone to DES

Read more

Summary

Introduction

As one of the most successful surgical interventions, cataract surgery involves removing the opaque lens of the eye and replacing it with an artificial lens. Most patients achieve excellent postoperative visual acuity, tear film dysfunction associated with surgical procedures remains a major challenge[1,2,3,4,5]. The application of topical eye drops, impaired corneal sensitivity, and surgery-related inflammation are thought to contribute to postoperative tear film dysfunction[6,7,8,9]. Only one study has addressed changes in tear film and tear secretion in diabetic patients after cataract surgery. The aim of this study was to evaluate the tear film parameters and ocular symptoms in diabetic and nondiabetic patients undergoing cataract surgery without DES at baseline and to determine whether diabetic patients are more predisposed to the development of DES postoperatively

Objectives
Methods
Results
Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.