Transient strain differences in an operant delayed non-match to position task

Abstract

Working memory refers to the temporary retention of a small amount of information used in the execution of a cognitive task. Working memory impairments are one of the common hallmarks of many neuropsychiatric and neurological disorders including schizophrenia and Alzheimer’s disease. Here, we investigated Fischer 344 and Long-Evans rats for strain and sex differences in working memory using the operant-based DNMTP task. Rats were required to press one of two levers presented during a sample phase and followed by a 2–32 second delay, the rats were then required to press the opposite, nonmatch, lever during the choice phase. We found a transient strain difference with Fischer 344 rats performing better than Long-Evans early in training. The Fischer 344 strain showed stable performance across sessions while the performance of Long-Evans increased in the later sessions. Since different background rat strains are used for transgenic rat models, it is critical to be able to compare the behavioral performance across different strains. These findings have implications in behavioral neuroscience research as understanding the typical behavioral endpoints in different background strains will aid our understanding of how different models affect behavioral performance.