Abstract
Abstract
 Background: Transient ischemic dilation (TID) measures left ventricle (LV) volume changes which can be associated with combination of myocardial and endocardial ischemia. Various stress methods, single photon emission computerized tomography (SPECT) imaging protocol, camera and software incite controversy on TID cut off. The purpose of this study was to evaluate the TID ratio in detection of coronary artery disease (CAD) categories in a systematic review and meta-analysis. Method: We conducted a systematic search of electronic databases (PubMed, Scopus, Embase and Web of Science) up to 1 January 2017. The reference lists of all included studies were searched for a higher accuracy. The search strategy was according a defined PICO as P: none, I: Transient ischemic dilation, O: Coronary Artery Diseases, C: Angiographies. Statistical analysis was done by Comprehensive meta-analysis software version 2 (CMA-2).
 Result: After study selection process, 7 studies were selected for data extraction. TID was studied from 1987. The sample size of included studies ranged between 86 and 545. The mean age of included patients varied between 58 and 69 years old. Ranges of TID in CAD categories were excluded. The pooled estimates of TID in single and dual pharmacological stress test in three CAD categories were calculated.
 Conclusion: Our findings show that more studies are needed to compare the TID variability. Although in this study meta-analysis was done and TID was summarized from studies but the software differences were ignored.
Highlights
Transient ischemic dilation (TID) is defined as post-stress left ventricular (LV) cavity dilation visualized in single photon emission computed tomography (SPECT) imaging.[1]
We found a significant difference in TID between 1) normal or no significant group and mild to moderate group (0.034 with 95% CI of 0.007, 0.061), 2) mild to moderate group and severe or extensive group (0.085 with 95% CI of 0.017, 0.152) and 3) normal or no significant group and severe or extensive group (0.113 with 95% CI of 0.049, 0.177)
Our findings show that there is a significant association between TID ratio and severity of coronary artery disease
Summary
Transient ischemic dilation (TID) is defined as post-stress left ventricular (LV) cavity dilation visualized in single photon emission computed tomography (SPECT) imaging.[1]. TID is a reliable indicator of LV volume changes which is repeatedly reported to be associated with both myocardial and endocardial ischemia.[2]. Transient ischemic dilation (TID) indicates left ventricle (LV) volume changes which can be associated with both myocardial and endocardial ischemia. The purpose of this study was to evaluate any association between TID ratio and severity of coronary artery disease (CAD) involvement in a systematic review and meta-analysis. The search strategy was according to a defined PICO as P: susceptible patients for CAD, I: Transient ischemic dilation, C: Angiographies, O: Severity of CAD. Ranges of TID in different groups were extracted as mean±SD and were compared based on severity of CAD. Conclusion: Our findings show that there is a significant association between TID ratio and severity of coronary artery disease. Performing more studies in this field can help future researchers to update this meta-analysis with subgroup analysis based on different techniques
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