Transient Induction of Fever in the Imiquimod C57BL/6 Mouse Model of Psoriasis-Like Disease Involves IL-1 and IL-6 but Not IL-36

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Psoriasis embodies a number of related chronic inflammatory skin conditions. Plaque psoriasis is the most common form and affects 1–3% of the population in many Western countries, whereas generalized pustular psoriasis (GPP) is a much rarer severe form. In addition to skin manifestations, patients with GPP also exhibit several signs of systemic disease, including fever, elevated serum CRP levels, and general malaise (Marrakchi et al., 2011; Onoufriadis et al., 2011). GPP is associated with mutations in the gene encoding the IL-36Ra (Marrakchi et al., 2011; Onoufriadis et al., 2011).