Abstract
We present here a 50-year-old male with a past medical history of aplastic anemia secondary to myelodysplastic syndrome who presented to the hospital with the chief complaint of severe generalized weakness due to acute anemia. He was transfused one unit of blood and developed ARDS 4 hours later. He was diagnosed with transfusion-related acute lung injury and discharged home after symptomatic management. This case report is a typical case of TRALI and deserves to be published in order to inform the general public of clinicians about TRALI, with the goal to improve the notification rate to hemovigilance which remains very low.
Highlights
Transfusion-Related Acute Lung Injury (TRALI) is characterized by sudden acute respiratory distress following transfusion
We present here a 50-Year-old Male with a past medical history of aplastic anemia secondary to myelodysplastic syndrome who presented to the hospital with the chief complaint of severe generalized weakness and shortness of breath on exertion
TransfusionAssociated Dyspnea (TAD) is acute respiratory distress occurring within 24 h of transfusion which fails to meet criteria for TRALI, Transfusion-Associated Circulatory Overload (TACO) or anaphylactic transfusion reaction
Summary
Transfusion-Related Acute Lung Injury (TRALI) is characterized by sudden acute respiratory distress following transfusion. Transfusion-Related Acute Lung Injury (TRALI) may be a lethal adverse reaction in 5 to 15% of cases. Respiratory status returns to pre-transfusion levels within 48 to 96 h and CXR returns to normal within 96 h.
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