Transformations based on ring-opening of gem-difluorocyclopropanes

Abstract

gem-Difluorocyclopropanes are an important fluorinated class of compounds with applications in medicinal chemistry, material sciences and organic synthesis. The transformations based on their ring-opening reactions have been recognized to be useful methods for rapidly synthesizing various fluorinated organic molecules. In this digest paper, we describe these efforts and highlight their powerfully potential and applications as fluorine-containing synthons in organic chemistry.