Abstract
PHOSPHONOACETIC acid (PAA) is an inhibitor of herpes simplex virus and of several other herpes viruses. It acts as a specific inhibitor of two viral DNA polymerases, those of herpes simplex and of Marek's disease (a herpes-induced leukaemia in chickens)1,2. We have used PAA as a probe to investigate the possible existence of a virus-directed DNA polymerase and its role in replication of viral genomes during the transformation and proliferation of normal human peripheral lymphocytes induced by Epstein–Barr virus (EBV), -which is a herpes virus closely associated with the development of several neoplasms in man.
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