Abstract
Phosphonoformic acid trisodium salt (PF) and ethyl diethylphosphonoformate (Et-PF) inhibited Epstein—Barr virus (EBV) viral capsid antigen (VCA) synthesis in B.95-8 cells, at concentrations which were nontoxic to cells. PF inhibited 96.7% of VCA synthesis when used at 500 μM whereas Et-PF inhibited only 68.9% of VCA synthesis when used at 2000 μM. The synthesis of EBV nuclear antigen (EBNA) was not inhibited by PF or Et-PF. PF inhibited the transformation of human cord blood lymphocytes (CBL) by EBV as detected by [ 3H]thymidine uptake. The inhibition of transformation was a function of the dose of PF used. A concentration of 2000 μM PF completely inhibited the transformation; the same concentration of ET-PF had almost no effect.
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