Abstract
AbstractAny synthetic transformation using contact‐explosives primary amines and hypervalent iodine(III) (phenyliodine diacetate) in constrained media (extreme conditions) is practically impossible. Herein, we report a method of controlling the explosion into a successful chemical reaction using the acid‐salt NaHSO4. As a proof‐of‐concept, we considered mechanochemical (ball‐milling) cross dehydrogenative coupling (CDC) reaction for the amidation of aldehydes via CH activation. An isothermal titration calorimetric (ITC) study was helpful to understand the enthalpy changes during the reactions before and after addition of NaHSO4.magnified image
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