Transfersomes — A Nanoscience in Transdermal Drug Delivery and Its Clinical Advancements

Abstract

The convenient nanotransdermal delivery system is always likely to have some ideal and unique characteristics, predominantly for safety, desired actions, clinical efficacy, enriched with a therapeutic index with minimal adverse occurrence. One of the most challenging tasks for the formulators is to transfer the medicament, especially macromolecules, through the skin. Some of the ways to achieve this is the use of a painful needle or some other methods which also have economical constraints. A new technology has been developed, that is ultradeformable liposomes, also called as transfersomes. These are an elastic type of lipid vesicle aggregates capable of delivering wide range of active moieties including various biomolecules. It can be manufactured by evaporation, vortexing, reverse-phase evaporation, ethanol injection or freeze-thaw methods, where phospholipids and edge activators are the major ingredients that contribute the main role in their unique mechanism of permeation through less permeable stratum corneum. This review mainly focuses on the clinical trial studies and patents accessible on transfersomal products worldwide, highlights the recent work on transfersomes with various therapeutic agents. An effort to explain the deeper penetration of transfersomes across the epidermis layer by its pharmacokinetics and dynamic properties has been taken.