Abstract
Hexagonal boron nitrides (hBNs) are promising nanomaterials with their high boron content, non-toxic nature in inactive form, high chemical stability, and mechanical strength. However, their hydrophobic nature limits their use in biomedical applications. Therefore, the hBNs have been functionalized with DSPE-PEG-NH2 to increase their colloidal stability and circulation time in bloodstream as well as to provide active sites on their surface for further functionalization with tumor-targeting agents. Then, further functionalization of the DSPE-PEG-hBNs with transferrin (TfR) was applied for selective targeting of transferrin receptors overexpressed by brain tumor cells. After that, the cellular interaction and biocompatibility of the structure was investigated on glioblastoma multiforme (U87MG) cancer cells. The cellular investigations showed that transferrin functionalization of the DSPE-PEG-hBNs increased their uptake by glioblastoma cancer cells and decreased cell viability due to the enhanced cellular internalization. Based on the data, the TfR-DSPE-PEG-hBNs are promising agents to evaluate them in drug carrying and targeting applications.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
