Transferosomes: Vesicular Carrier for both Hydrophilic and Lipophilic Drugs

Abstract

The vesicular system has accessed significant importance towards a sustained drug delivery system in recent years. This article was designed to review the future of vesicular systems known as transferosomes. The vesicles are softer and highly deformable than liposomes. The word Transferosomes is derived from Latin and Greek words called “Transferre” and “soma,” respectively, where Transferre means “carry across” and Soma means “a body.” Transferosomes vesicles are carrying bodies for targeted transdermal drug delivery systems. It consists of phospholipid and an edge activator. In transferosome, phospholipids vesicles act as transdermal drug carriers. It generates an osmotic gradient at the stratum corneum and helps the transferosomes penetrate through the stratum corneum by the transcellular route. Transferosomes have a wide range of solubility, have a remarkable ability to penetrate through the skin, are compatible and biodegradable, and are highly expensive. But they are easily prone to chemical degradation and are highly expensive. The transfersomes were formulated by handshaking, vortex, and freeze-thaw techniques. Transferosomes have various Evaluation parameters such as Vesicle size distribution, the morphology of vesicle, Number of vesicles per cubic mm. Transferosomes have various applications like they can be applied in controlled release and sustained release formulation, transportation of lower and higher molecular weight drug molecules, target drug delivery system, and transdermal immunization. Transferosomes have been ultra-deformable vesicles capable of subjecting a futuristic solution to all vesicular delivery and conventional delivery complications. It can carry any drug’s molecular weight through the skin; due to its ultra-deformable characteristics feature, therefore, they are widely used to take protein and peptides. After doing all the evaluation studies, we can say that Transferosomes are the promising candidate for the vesicular system and can replace other novel vesicular systems. Thus it holds a bright future in novel drug delivery systems.