Transfersomes: An Innovative Vesicular Carrier for Boosted Transdermal Delivery System

Abstract

One may find difficulties with oral and parenteral drug delivery systems in a routine of clinical practice because they do not have sufficient compliance and bioavailability for patients. So, nowadays transdermal route is a greater area of interest of pharmaceutical research for delivering drug. But skin is the most challenging area to cross in transdermal delivery of drug as the stratum corneum & the outer layer of the skin have tight intracellular junctions. Researchers have developed various approaches like micro needle, sonophoresis, electrophoresis, and iontophoresis etc to overcome those complications for the transdermal delivery of drugs. Chemical permeation enhancers are needed in vesicular drug delivery system such as niosomes, liposomes, elastic liposomes (transfersomes and ethosomes) to improve their penetration property. Transferosomes can be prepared by a number of methods like vortexing, sonication method, freeze–thaw method, ethanol injection method, Reverse-phase evaporation method, etc. Transfersomes can carry wide ranges of drugs having a wide range of solubility within it as they are constructed of hydrophobic as well as hydrophilic moieties. The main property of transferosome is deformability. This flexible nature of the vesicle membrane helps transfersome to go across the narrow pores with a maximum amount of drugs present within it. They have high deformable capacity which exhibits advanced penetration capability of intact vesicles. Both high and low molecular weight drugs like albumin, insulin, corticosteroids, sex hormones, anesthetic, anticancer, analgesic can be fused within transfersome.