Abstract
This chapter describes the transfer of cellular reactivity to three nonhuman primate species with human and baboon transfer factor (TF). Three primate species have been evaluated for their ability to convert in vivo and in vitro cellular immune responses in vivo subcutaneous administration of TF from either human or nonhuman primate donors. Primates included the baboon, the cebus monkey and the cotton-top marmoset. The particular species were selected because they exhibit varying susceptibility to infectious and oncogenic agents, and also demonstrate differences in cellular immune competence and baboon immunologic responses are relatively normal, those of the cebus are intermediate and the cotton-top marmoset is deficient, using criteria developed for humans. Gross inspection of skin tests and in vitro assay of lymphocyte blastogenes is appeared to be sensitive and reliable methods of demonstrating transfer in primates. There were no significant differences observed between the three primate species either in their responses human TF or baboon TF. The limited number of animals examined may have obviated recognition of more subtle species differences.
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