Abstract
AbstractThe transfer hydrogenation of flavanones and ortho‐hydroxychalcones catalyzed by ruthenium pincer complexes RuCl(CNNPh)(disphosphine) has allowed the synthesis of ortho‐hydroxy 1,3‐diarypropanols in 80–88 % yield, under mild reaction conditions and short reaction times (1 h) in 2‐propanol. The amount of the co‐catalyst NaOiPr has been found crucial for the selective reduction of flavanones to ortho‐hydroxy 1,3‐diarypropanols vs. flavan‐4‐ols. Preliminary results show that with pincer catalysts bearing (S,R)‐Josiphos, flavanone is reduced to the corresponding (S)‐alcohol in moderate conversion (36 %) and up to 92 % ee.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
More From: ChemCatChem
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
