Transfer Factor Therapy in a Patient with an Isolated T-cell Deficiency

Abstract

This chapter discusses a case study undertaken to study effect of transfer factor (TF) therapy in patient with an isolated T-cell deficiency. The chapter states that treatment of patients with immunodeficiencies with TF is not only important therapeutically but may also be useful in the classification of T-cell diseases which overlap in the spectrum of immunodeficiency disorders. In the case study, a lung biopsy showed mild interstitial fibrosis and a moderate mononuclear cell infiltrate into the alveolar septa which was interpreted as bronchiolitis obliterans. It was observed that the humoral immune or B-cell system appeared to be completely normal. The tests revealedthat the success of TF therapy in immunodeficiency diseases seems to correlate with a certain critical level of T-cell differentiation. The results showed that in the case study patient, the response to TF therapy favors a defect in T-cell maturation beyond that of the defect in Nezelof's syndrome.