Transdermal patches of lidocaine/aspirin ionic liquid drug-loaded gelatin/polyvinyl alcohol composite film prepared by freeze-thawed procedure.

Pattwat Maneewattanapinyo,Jirapornchai Suksaeree,Wiwat Pichayakorn,Kamon Panrat,Fueangfah Watthana,Alisa Yeesamun

doi:10.1590/0001-3765202020191073

Pattwat Maneewattanapinyo, Jirapornchai Suksaeree + Show 4 more

Open Access

https://doi.org/10.1590/0001-3765202020191073

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Abstract

The objectives of this study are to prepare a 5 wt% lidocaine/aspirin ionic liquid drug-loaded gelatin/polyvinyl alcohol composite film using a freeze-thaw procedure and to evaluate their physicochemical characteristics, in vitro drug release, and stability. Lidocaine/aspirin ionic liquid drugs can be prepared by an ion-pair reaction between the hydrochloride salts of lidocaine and the sodium salts of aspirin, which showed a significant change in their thermal properties when compared to those pure drugs. The results showed that a transdermal patch could feasibly be used in pharmaceutical transdermal patches with good physicochemical properties. A chemical interaction between the drug and polymer base was not found. Decomposition of the lidocaine/aspirin ionic liquid drug was found in the patch; however, the properties of the patch were not changed after drug loading. The patch controlled the drug release and showed good stability during the studied period of three months when kept at 4°C more than at ambient temperature and 45°C.

Highlights

Transdermal polymeric patches are lowcost systems used to treat numerous noncommunicable diseases
The dichloromethane was used as an organic solvent to extract the final product of a lidocaine/aspirin ionic liquid drug
A gelatin/polyvinyl alcohol composite filmloaded lidocaine/aspirin ionic liquid drug can be prepared by a freeze-thawed procedure with a high feasibility to be used in pharmaceutical transdermal patches

Summary

Introduction

Transdermal polymeric patches are lowcost systems used to treat numerous noncommunicable diseases (e.g., non-infectious and non-transmissible pathologies). Ionic liquids reach liquid form at room temperature and have a melting point below 100° C (MacFarlane et al 2006, Sowmiah et al 2009, Torimoto et al 2010). They have good peculiar properties such as high chemical and thermal stability, low volatility, lack of inflammability, and negligible vapor pressure

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