Abstract
Abstract Cellular metabolism can orchestrate immune cell function. We previously demonstrated that lipid biosynthesis represents one such gatekeeper to Th17 cell functional state, promoting autoimmune responses in the experimental autoimmune encephalomyelitis model. Utilizing a transcriptome-based insilico fluxomics tool, we investigated ancillary metabolic pathways associated with Th17 cell function and studied in detail the relevance of the polyamine pathway as modulators of autoimmune inflammation. We investigated this pathway using carbon-tracing fluxomics, transcriptomics, epigenomics (ATACseq) and functionally validated their relevance in autoimmune disease models using small molecule inhibitors and knockout animals.
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