Abstract
OPINION article Front. Immunol., 08 September 2015Sec. Multiple Sclerosis and Neuroimmunology https://doi.org/10.3389/fimmu.2015.00455
Highlights
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease that affects the central nervous system (CNS) resulting in progressive cognitive decline and physical disability
Our studies, supported by recent results from other labs, suggest that the pathogenic function of γδ T cells is mediated by their production of IL-17 and related cytokines, including IL-21 and GM-cerebrospinal fluid (CSF) [28]. γδ T cells can secrete IL-17 in response to IL-1, IL-18, and IL-23 without T cell receptor (TCR) engagement, promoting the induction of Th1 and Th17 cells and amplifying their encephalitogenic function during the development of EAE [28, 37, 38] (Figure 1)
Understanding the Th17/IL-17 axis in both protective and dysregulated immunity has led to the development of many promising front line therapies for autoimmune diseases
Summary
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease that affects the central nervous system (CNS) resulting in progressive cognitive decline and physical disability. In addition to IL-17A, Th17 cells produce an array of other inflammatory cytokines, including IL-17F, GM-CSF, IL-22, IL-21, IL-26 and TNF-α [16, 18,19,20,21,22,23,24] Since their discovery, Th17 cells have been implicated in the pathogenesis of most common autoimmune diseases, including psoriasis, rheumatoid arthritis (RA), and MS, and in animal models of these diseases. Our studies, supported by recent results from other labs, suggest that the pathogenic function of γδ T cells is mediated by their production of IL-17 and related cytokines, including IL-21 and GM-CSF [28].
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