Abstract
Psoriasis is a common chronic inflammatory skin disease characterized by abnormal proliferation/differentiation of keratinocytes (KCs) and increased immune cell infiltration in the dermis and epidermis (Greb et al., 2016). Although immune cells are considered to be the main driver of psoriasis, KCs may also be implicated in triggering psoriasis and in sustaining inflammation in psoriatic skin (Ni and Lai, 2020). Psoriasis can manifest clinically in several different ways (Boehncke and Schön, 2015), but the rare observation that some individuals may present with psoriasis along the lines of Blaschko (Blaschko, 1901), that is, in a distribution fitting lines of epidermal development and therefore inherent KC pathology (Happle, 1993), provides an opportunity to dissect KC pathobiology in psoriasis in more detail.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
