Abstract
A high proline diet (50% gelatin) was found to induce a 3–8 fold increase in the activity of rat small intestinal angiotensin-converting enzyme and dipeptidyl peptidase IV. Induction was also accompanied by a increase in steady state levels of enzyme mRNA. It was observed that the rate of gene transcription for these two enzymes is increased to levels corresponding to the changes in their mRNA. These results indicate for the first time that dietary components can influence the expression of various intestinal brush border membrane hydrolases at the level of gene transcription.
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