Abstract
The transcription of genes by eukaryotic RNA polymerase II is regulated by cis-acting DNA sequences (promoters and enhancers), which probably exert their effects on transcription through interactions with trans-acting protein factors. Some trans-acting factors can interact with DNA elements in a number of different enhancers or promoters in a variety of cell types. However, other factors may be involved in conferring such characteristics as tissue specificity or inducibility on enhancers, or in regulating gene expression at different stages of development. Few trans-acting factors have been purified or characterized, and their mechanisms of action are unknown, though cooperative binding and other protein-protein interactions are likely to be involved.
Published Version
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