Abstract
The authors present their series on frontobasal carcinomas of the anterior skull base as well as their experience with the transbasal approach. From 2006–2008, five patients (three men, two women; average age, 58.6 years) underwent surgery that used the transbasal approach by means of bifrontal craniotomy and microsurgical resection of the intracranial portion and sphenoid and ethmoid sinuses. All patients were smokers. All cases were researched to determine whether the primary place of carcinoma was outside skull base, and all were confirmed to have the primary tumor in the skull base. The resection was subtotal in all cases, and CSF leakage was observed in the postoperative period. Preoperative visual impairment and anosmia were the most frequent findings. Closure of the operative hole was performed using Porex in two cases. Closure for the other three cases was done with a piece of frontal flap bone, along with abdominal fat, muscle, and fibrin glue, and was completed by the endoscopic endonasal approach using a mucoperichondrial flap. Lumbar drainage was used in all cases. All cases were referred for treatment with radiotherapy devices and also received systemic chemotherapy with cisplatin. The average follow-up was 9 months (range, 1–24 months). One case died due to recurrence after 15 months, with leptomeningeal extension of the lesion.
Published Version
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