Abstract
Objective To evaluate the feasibility of transarterial prostate embolization for reducing the volume and its technical safety in hormone-induced dogs prostate hyperplasia. Methods Prostate hyperplasia was induced on 12 adult male dogs by administering testosterone propionate for 12 weeks.Then,the dogs were randomly assigned to transarterial prostatic embolization group (n=6) and control group (n=6).Twelve weeks after initiating the hormone treatment,6 animals in transarterial prostatic embolization group underwent prostatic arterial embolization with Embospheres 100—300μm in diameter.Based on MRI,the volume of prostate was measured for both groups on the three time points: before injection of hormone (BI),before the procedure of prostatic arterial embolization (BP) and 12 weeks after the procedure of prostatic arterial embolization (AP).Finally,the prostates and surrounding tissues were harvested for histopathology study.A statistical software package (SPSS version 19.0) was used for analysis.Measurement data were expressed as x± s.Samples paired t test was used to compare the prostatic volume between BP and AP.The t test was applied in the intergroup comparison.P<0.05 was considered to indicate a statistically significant difference. Result s The successful rate of BPH model establishment and superselective catheterization were 100%.No serious procedure-related complication was observed.After 12 weeks of hormone administration,the mean volume of prostate was 19.5±2.5 mm3in embolization group and 19.2±3.8 mm3in control group before prostatic arterial embolization,without statistical difference (t=0.14,P>0.05).At 12 weeks after prostatic arterial embolization,the mean volume of prostate was 6.1±1.4 mm3in embolization group and 17.8±3.5 mm3in control group with significant statistical difference (t=-7.6,P 0.05).Histopathology study revealed that embosphere particles had occluded partial arterioles of the prostate in the embolization group of dogs.Near the occluded arterioles,normal gland structure disappeared; while residual gland tissue appeared to be atrophied.In embolization group,there was no gross or microscopic change in the surrounding tissues including bladder,deferent duct and rectum.Extensive prostate glandular hyperplasia was observed in control group. Conclusions Transcatheter arterial embolization is feasible for reducing prostate volume without serious complication in hormone-induced prostate hyperplasia dogs and worthy of further investigation. Key words: Prostatic hyperplasia; Embolization,therapeutic; Angiography,digital subtraction;Animals,laboratory
Published Version
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