Trans-Sphenoidal Surgery for "Growth Hormone-secreting adenoma; Revisiting Surgical Outcome

Abstract

Objective: The purpose of this research is to review our clinical experience in transsphenoidal surgery for pituitary adenomas performed by Recep Tayyip Erdogan University Faculty of Medicine, Department of Neurosurgery and contribute to the literature in this way.Methods: This is a case review of Growth Hormone secreting pituitary adenoma operated in the Recep Tayyip Erdogan University Faculty of Medicine Department of Neurosurgery from January 2014 to May 2021. All patients underwent a microscopic transnasal approach. It was aimed gross total excision of adenoma. For functioning adenomas, hormonal assessment was done on follow-up (8 weeks) and remission was said to be achieved if normal hormonal levels were achieved along with gross total tumor removal. Surgical complications were evaluated, and postoperative follow-up with laboratory and imaging studies were performed.Results: 78 patients were operated by trans nasal route in our hospital between January 2014-June 2021. Of these 78 pituitary tumors, 22 were growth hormone secreting adenoma. The study population consisted of 22 people, 11 men and 11 women, and the average age of the population was calculated as 60.45 years ± 18.4. Statistical analysis showed that the difference between the pre-operative and post-operative somamedine and growth hormone level was statistically significantConclusions: Microscopic Trans-Sphenoidal Surgery for Acromegalic patients is a minimally invasive, safe, and efficacious choice