Abstract
Resveratrol is a naturally produced compound that has been well researched for its potential health benefits. The primary hindrance towards resveratrol’s therapeutic efficacy is its traditionally poor oral bioavailability. LipiSperse® is a novel delivery system designed to increase the dispersion of lipophilic ingredients, like resveratrol, in aqueous environments. This single-dose, double-blind, randomized study compared the pharmacokinetics of a commercially available resveratrol with (Veri-Sperse®) and without (Veri-te) the LipiSperse® delivery complex. Healthy adults randomly received a single dose of either 150 Veri-te, 75 Veri-Sperse®, or 150 mg Veri-Sperse®. Venous blood samples were taken prior to dosing in a fasted state and at 0.5, 1, 2, 3, 4, 5, 6, 8 and 24 h post supplementation. Plasma trans-resveratrol conjugates were measured by liquid-chromatography tandem mass spectrometry (LC-MS/MS). The area under the curve (AUC) (0–24 h), maximum concentration (Cmax), and time of maximum concentration (Tmax) of plasma conjugates were calculated. The 150 mg dose of Veri-Sperse® had a 2-fold increase in absorption (AUC) and a 3-fold increase in Cmax of trans-resveratrol conjugates compared to 150 mg Veri-te. There was no statistical difference between 75 Veri-Sperse and 150 mg Veri-te for AUC or Cmax of resveratrol conjugates. These findings provide support for the use of LipiSperse® to improve absorption of resveratrol.
Highlights
Resveratrol is a natural product produced in grapes and other plants as a defense against UV radiation, environmental stress, and fungal infections [1]
The current study examined the effects of LipiSperse®, a novel delivery system that uses dispersion technology to enhance the absorption of hydrophobic agents, on the absorption of a commercially available resveratrol ingredient
Due to the rapid metabolism and comparably low levels of free trans-resveratrol, this study focused on the trans-resveratrol conjugates to assess the efficacy of LipiSperse® for increasing absorption
Summary
Resveratrol is a natural product produced in grapes and other plants as a defense against UV radiation, environmental stress, and fungal infections [1]. Resveratrol accounts for more than 12,000 scientific studies and 170+ human clinical trials [2], making it a well-studied functional ingredient within the dietary supplement industry. Ingested resveratrol at dosages between 6 and 5000 mg per day have been documented as safe [3]. Known for its protective heart-health benefits [4], research indicates that resveratrol taken in modest amounts can play a broader role. Clinical studies administering 75 to 500 mg/day have shown that resveratrol can benefit: Vascular [5] and heart health [6], cognitive [7] and mental performance [8], bone mineralization [9], physical activity [10], positive modulation of the gut microbiome [11], eyesight [11], and oral inflammation [12]. Resveratrol’s efficacy is evidenced through the upregulation of enzymatic antioxidants (e.g., catalase (Cat), superoxide dismutase (SOD)), and markers for chronic inflammation (e.g., CRP, IL-6, TNF-α)
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