Abstract
s / Osteoarthritis and Cartilage 22 (2014) S57–S489 S423 in the degeneration of the joint cartilage and pain. The rats showing pain-related behaviors were selected for the evaluation of TG-C for its individual cell type (1. hChonJ; 2. hChonJb#7; or 3. TG-C (hChonJ and hChonJb#7)) for pain and cartilage regeneration. At twoweekspost MIA administration, the individual cells were injected into the osteoarthritic knee cavity. The effect of the cells on the mechanical allodynia was evaluated by von Frey filament test in blinded fashion. After completing the test, the knees were harvested for histological analysis. Results: In MIA model, the reduction of pain was observed in hChonJ#7 treated and TG-C treated groups from day 15 post injection but not in hChonJ alone or in untreated group. The magnitude of pain reduction in hChonJ#7 treated group was comparable to that of TG-C treated group up to day 28. However, TG-C showed longer and greater pain reduction thereafter up to 8 weeks, indicating synergy between hChonJ and hChonJ#7 cells. The histological analysis showed that the integrity of cartilage was severely damaged by MIA treatment. However, hChonJ#7 cell treatment improved the damaged cartilage, in addition, TG-C treatment showed even greater improvement in the regeneration of the cartilage. Conclusions: This study showed that TG-C treatment could reduce pain and regenerate damaged cartilage in a rat MIA osteoarthritis model and contributes to the understanding of the effect of TG-C on the improvement of clinical outcomes observed in phase 2b trials. 763 TRADITIONAL CHINESE HERBAL MEDICATED BATH THERAPIES FOR OSTEOARTHRITIS B. Chen y, M. Chung z, H. Zhan y, Y. Cao y, C. Wang z. y Shuguang Hosp. Affiliated to Shanghai Univ. of Traditional Chinese Med., Shanghai, China; z Tufts Med. Ctr., Boston, MA, USA Table 1 Effect of traditional Chinese herbal medicated bath therapy on knee osteoarthritis Author year N Age Bath therapy (formula, water temperature, dose) Control intervention Li, 2011 204 63 14 Herbs: 9-30g each, 30 min, twice a day. Loxoprofen, 60 mg, 3/day Zhang, 2012 96 58 14 Herbs: 6-15g each, 30 min, twice a day, Hyaluronate injection, 2ml/wk Hyaluronate injectio 1 2ml/1 wk Du, 2012 60 63 9 Herbs: 12-15g each, 40-45 C, 20-30 min, 2x/day. Diclofenac topical c 2#/ day. Chen, 2013 60 57 10 Herbs: 5-30g each, 35-60 C, 30 min, 1-2x/day Diclofenac diethylam 2/day Zhang, 2011 90 58 8 Herbs: 5-15g each, 20 min, once or twice a day Diclofenac sodium, 75 mg/day Wu, 2011 98 55 8 Herbs: 20g each, 40 min, every other day Acupuncture. Meloxicam, 7.5 mg/ Huang, 2011 120 58 31 Herbs: 9-18g each, 20 min, twice a day. Oral herbal medicine Hyaluronate injecti
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