Abstract
The carcinoembryonic antigen (CEA) family plays an important role in numerous normal and pathogenic processes related to cellular growth and differentiation. Crucial roles of various CEA-family members are well established while the effect of carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) on immune-cell function has only recently been recognized. CEACAM1 is known to exist in both monomeric and dimeric states that are heterogeneously distributed at the cell surface. However, which form participates in cell-cell interactions and its related dynamics remain unknown. We report here details of CEACAM1's spatial distribution, oligomeric state, diffusional characteristics and dynamics as determined by live cell homo-fluorescence energy resonance transfer (homo-FRET) microscopy and imaging total internal reflection fluorescence correlation spectroscopy (ITIR-FCS).
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