TP53 codon 72 polymorphic variants (Rs1042522) frequency in the Ukrainian population

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To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population. We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele specific polymerase chain reaction. We identified 31 individuals (20.9 %) with Arg/Arg genotype, Arg/Pro genotype was identified for 116 indi viduals (78.4 %), whereas genotype Pro/Pro was rare and was found in one person only (0.7 %). Genotype distribu tions were not within Hardy Weinberg equilibrium (χ2 = 59,7, p < 0.0001). Arg and Pro allele frequencies in the population of Ukraine are 60 and 40 % respectively, which is sig nificantly differ from the frequencies described in the literature for Poland, the Czech Republic, the USA and Brazil.