Abstract
This study was conducted to evaluate oxidative stress using markers such as malondialdehyde (MDA), glu- tathione (GSH), total oxidant status (TOS), total antioxidant capacity (TAC) and oxidative stress index (OSI) in sheep naturally infected with Toxoplasma gondii (T. gondii). A total of 30 Morkaraman breed sheep were used in this study. Blood samples were obtained from 10 healthy control sheep and 20 sheep naturally infected with T. gondii. malondial- dehyde, GSH, TOS and TAC levels were determined in serum samples. The ratio of serum TOS to TAC levels was assessed as OSI. While the serum MDA level increased significantly (P<0.01), the serum TAC and TOS levels de- creased significantly (P<0.01) in naturally infected with T. gondii sheep. There were no different for serum GSH and OSI in between the groups (P˃0.05). Negative correlation (P<0.01) between TAC and OSI and a positive correlation (P<0.01) between TOS and MDA were determined in naturally infected with T. gondii sheep. In conclusion, the results of study suggested that OSI, TAC and MDA could be used as indicator of oxidative stress for sheep naturally infected with T. gondii.
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