Toxicological studies of Astavarga Kvatha Curna, an Ayurvedic formulation, on liver function parameters of rat plasma

Abstract

Astavarga Kvatha Curna (AST) approved by the National Unani and Ayurvedic Formulary Committee of Bangladesh is widely used in the treatment of vata roga (neurological disorder) by the rural and ethnic people of this country. In the present study, the effect of this formulation on liver function parameters of rat plasma was examined after chronic administration. The animal used was albino rat (Rattus novergicus: Sprague-Dawley strains) and the drug was administered per oral route at a dose of 40 ml/kg body weight, once daily, up to 41 days for all the experiments. Forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. In both male and female rats, there was a statistically significant increase in the total protein (male, p=0.044*, female, p=0.043)*. In case of albumin, the increase in the male rats were statistically significant (p=0.003)** but it was statistically highly significant (p=0.001)*** in the female rats. In case of sGOT, sGPT and ALP, there was a statistically highly significant (p=0.001)*** increase in both male and female rats. The level of bilirubin was decreased in both male and female rats and it was statistically highly significant (p=0.001)***.