Effect of Ardhabilva Kvatha Curna, an ayurvedic formulation, on liver and kidney function parameters of rat plasma after chronic administration

Abstract

Ardhabilva Kvatha Curna (ADR), a widely used Ayurvedic formulation of Bangladesh, is the preparation of five important medicinal plants. In the present study, the liver and kidney function parameters of rats’ plasma were studied after chronic administration of ADR usually used in the treatment of Malabandha (obstructed feces). The animal used was albino rats (Rattus novergicus: Sprague-Dawley strains) and the drug was administered per oral route at a dose of 40 ml/kg body weight, once daily, up to 41 days for all the experiments. Forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. In both of the male and female rats, there was a statistically very high significant increase in Bilirubin and Creatinine (p=0.001***). Except ALP and total protein, the other parameters that demonstrates liver function also increased significantly in both male and female rats as sGOT (male, p=0.283, female, p=0.029*), sGPT (male, p=0.028*, female, p=0.008**). A decreased concentration of both ALP and total protein was observed in both male and female rats and it was not statistically significant. The increase in albumin content was statistically very high significant in both sexes of the animal (p=0.001***). A decreasing trend of both Urea and Uric acid content was noticed in male and female rats and incase of female rats, it was statistically significant (p=0.038* and p=0.048* respectively).