Abstract
BackgroundSpondias purpurea is a flowering plant of the cashew family commonly found in South Western Nigeria. The plant is used in folk medicine for treatment of gastric disorders and diarrhoea. The purpose of the study was to investigate the haematological and histopathological effects of aqueous and ethanol leaf extract of S. purpurea (red plum) in rats.MethodsFemale wistar rats weighing (121.5 ± 30.41 g) were administered 500, 1000 and 1500 mg/kg body weight of aqueous and ethanol extracts of S. purpurea leaf (orally) daily for 14 days, while the control group was administered 0.5 ml of normal saline (vehicle). At the end of the study, the rats were euthanized; blood samples were collected for haematological parameters. The liver, kidney and spleen were harvested from the rats for photomicrographic examination.ResultThe result of the acute toxicity test revealed no death with dose up to 5000 mg/kg body weight. The administration of the extracts showed no significant difference (p > 0.05) in the hematologic parameters of the animals. The liver sections showed congestion, mononuclear infiltration, widened sinusoidal space and congestions with hemosiderin. Similar changes were observed in the kidney showing slight necrosis of renal tubular epithelium, widened Bowman’s space, and collapsed renal tubules and adhesion of the parietal layer of glomerulus to the Bowman’s space. The spleen showed congestion, lymphocyte proliferation at the germinal centre.ConclusionsThe result of this study showed that the alterations observed in the organs intensified with increase in the doses of the extracts administered. It can be inferred that the prolonged consumption of S. purpurea leaf maybe associated with significant tissue damage of some vital organs.
Highlights
IntroductionNatural plant products are essential sources of food and the backbone of medicines attributable to the presence of bioactive agents which serve as materials for development of synthetic chemical compounds utilized to meet basic human needs [1, 2]
It can be inferred that the prolonged consumption of S. purpurea leaf maybe associated with significant tissue damage of some vital organs
Natural plant products are essential sources of food and the backbone of medicines attributable to the presence of bioactive agents which serve as materials for development of synthetic chemical compounds utilized to meet basic human needs [1, 2]
Summary
Natural plant products are essential sources of food and the backbone of medicines attributable to the presence of bioactive agents which serve as materials for development of synthetic chemical compounds utilized to meet basic human needs [1, 2]. Blood and (2021) 7:90 tissue disorders caused by the toxic effect of ingested plants, can be evaluated by haematological and histopathological studies due to its reliability and sensitivity [4]. Spondias purpurea commonly known as red plum belongs to the genus Spondias, of the family Anacardiaceae, which comprises of more than 70 genera and over 600 species [5]. They are mainly trees and shrubs growing in tropical, subtropical and naturalized in countries like Nigeria and Philippines [6, 7]. Some cultures in Nigeria, believe that S. purpurea possess haematinic potentials and consume decoctions made from the leaves of the plant. The purpose of the study was to investigate the haematological and histopathological effects of aqueous and ethanol leaf extract of S. purpurea (red plum) in rats
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
