Abstract
The organophosphorus compounds cythioate ( O,O -di-methyl O-p -sulfamoylphenyl phosphorothioate), famphur, and fenthion were administered intravenously, subcutaneously, and orally at varying concentrations to 101 female rabbits. Cholinesterase (ChE) activity levels of both plasma and red blood cells were tested, as was tick and mosquito ChE, at various times before and after dosage. These determinations measured the inhibition of ChE activity caused by pesticidal action. Correlations between fluctuations in blood ChE activity of the host and ChE activity of the ectoparasites were observed. Mortality of ectoparasites commenced at 32% ChE activity depression, and there was 100% mortality at 68% ChE activity depression. No mortality of ectoparasites occurred between the 24- and 96-hour postdosage period. Mated female ticks exposed to sublethal doses of pesticide did not lay eggs. Reduction in temperature was fatal to mosquitoes that had received sublethal doses of pesticide in their blood meal. Reproductive capabilities of rabbits were not impaired by therapeutic dosages of the pesticides.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call