Abstract
Tentacles of Calliactis polypus were homogenized and centrifuged, and the supernatant liquid was lyophilized. Mice receiving a phosphate buffer solution of the lyophilized material, ranging between 7.5 and 15.0 mg./kg. i.p., demonstrated a stuporous condition and respiratory distress; some died within 24hr. The LD50 in mice was 32 mg./kg. Doses of 5–15 mg./kg. produced a decrease in the blood pressure and bradycardia. These effects were abolished by bilateral vagotomy and atropinization. With higher doses, various arrhythmias and ECG abnormalities were observed. When tested on isolated rabbit heart, the extract caused a decrease in heart rate, force of contraction, and rate of coronary outflow. The extract produced contraction in the isolated rabbit duodenum, guinea pig ileum, and rat uterus by parasympathetic stimulation. These effects were abolished by atropine.
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