Abstract
Renilla mulleri specimens, collected from the Mississippi Gulf Coast, were homogenized and centrifuged, and the supernatant liquid was lyophilized. Mice injected with 100-250 mg./kg. i.p. of the lyophilized extract dissolved in phosphate buffer (pH 6.5) became lethargic, and most of them died within 24hr. The LD50 in mice was 160 mg./kg. A dose of 10-20 mg./kg. i.v. produced a fall in blood pressure and a distinct bradycardia in anesthetized cats. These effects were not abolished by either bilateral vagotomy, atropinization, or adrenergic blockade. At higher doses, the extract produced irregularities of heart actions. In isolated rabbit heart preparations, the extract produced a decrease in the rate and amplitude of cardiac contractions and the coronary outflow. The extract had a relaxant effect on isolated rabbit duodenum, guinea pig ileum, and rat uterus. The effect of the extract on the blood pressure, heart, and isolated smooth muscles is due to a direct myotropic effect.
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