Toxicological and hypoglycemic studies on the oil extracted from seeds of Khaya senegalensisis on blood glucose levels of alloxan-induced diabetic albino rats

Abstract

Diabetes mellitus is a metabolic disorder found in all nations of the world. It is one of the most prevalent epidemics of the 21st century. Despite the numerous research on this area, it effects are still on top gear. Nature has provided abundant plant which possesses medicinal values and several claims on the uses of plant by the traditional healers were also on the increase, yet no known solution. There is an obvious need to evaluate all these abundant plant for better use in medical practice. Hence, the present study aims at evaluating the diabetes claim of Khaya senegalensisis, and also to assess its safety. Aqueous oil extract of K. senegalensisis were subjected for hypoglycemic activity in 25 hyperglycemic induced Wistar rats. 3 different concentration (6, 3 and 1.5 mg/kg) of the extract were tested against a standard drug (500 mg/kg of metformin). Blood glucose lowering effect was determined using Accu-check glucometer. The oral administration of the extract shows hypoglycemic effect and its concentration dependent. However, the extract, does not significantly lower blood glucose levels as compared to the standard drug used as a positive control. Hence we concluded, that the extracted oil can serve as an alternative in the treatment of mild diabetes, we have equally show that at concentration tested, and no sign of toxicity was recorded. Key words: Toxicological, diabetes, effect, hypoglcemic.