Abstract
The aim of this study is to evaluate the importance of toxicological analysis in acute intoxications by pesticides through the experience of the laboratory of the Poison Control and Pharmacovigilance Center of Morocco (CAPM). This is a retrospective study from January 2014 to September 2020, concerning suspected pesticides poisoning cases. The cholinesterase activity was measured in whole blood and the chromatographic analyzes (GC-MS and LC-MS-MS) were conducted in blood, urine and gastric lavage fluid. In this study, 398 tests were involved. The median age of the patients was 14 with an interquartile range of [4-26 years]. The sex ratio (F / M) was 1.5. The requests were from the region of Rabat-Salé-Kénitra in 82.8% of cases (north-western Morocco). The cholinesterase activity measurement was performed for 295 patients with low values in 3.7% of cases. The toxicological screening by GC-MS and LC-MS-MS detected the pesticide responsible of poisoning in 62 cases as insecticides in 38% of cases, redenticides (33% of cases) and herbicides (5% of cases). Toxicological analysis plays an essential role in the diagnosis and the management of acute pesticides poisoning. Interpretation of results is carried over by analyst with close cooperation with clinical toxicologist.
Highlights
Pesticides are used across the world to protect crops, plants in agriculture, gardens or domestics, against insects, rodents or any pests threating the public health
The aim of this study is to evaluate the importance of toxicological analysis in acute intoxications by pesticides through the experience of the laboratory of the Poison Control and Pharmacovigilance Center of Morocco (CAPM)
This is a retrospective study from January 2014 to September 2020, concerning suspected pesticides poisoning cases
Summary
Pesticides are used across the world to protect crops, plants in agriculture, gardens or domestics, against insects, rodents or any pests threating the public health. This chemical molecules causes above of 5 million of intoxications annually, according to the World Health Organization (WHO) [1]. The misuse of the pesticides is the main cause of this type of intoxication. The same center reported, 11196 acute pesticides poisoning cases, in Morocco from 2008 to 2016 [3]. Analytical methods, especially chromatographic ones, facilitate the detection and the quantification of pesticides in biological samples and contribute in the diagnostic and the management of acute poisoning cases.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call