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Abstract
Rats received 40, 80 and 160 mg KCN/kg body wt./24 h in the drinking water for 13 weeks. Fairly constant dose-related cyanide and thiocyanate levels were measured in blood, plasma and urine during the exposure. Blood cyanide concentrations were in the range of 16.0–25.5 nmol CN −/ml blood, thiocyanate concentrations in the range of 341–877 nmol CN −/ml plasma following continuous administration of the maximum tolerated dose-level of 160 mg/kg body wt/24 h. The results suggest that continuous 13 week maximum tolerated cyanide exposure does not lead to saturation of cyanide detoxification pathways.
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