Abstract
Male rats were employed to study the blood and liver cyanide (CN) concentrations after oral doses of 6, 10 and 14 mg potassium cyanide (KCN)/kg body weight. Animals killed 10 min after administration had higher blood CN concentrations than those killed near death or at survival. The minimum lethal blood CN concentration in rats was found to be in the range 2.60–2.92 μg/ml. Liver CN concentrations were generally lower than the corresponding blood CN concentration for all dosage groups studied. This was probably due to the CN detoxification capability of the liver. Lethal liver CN concentrations were in the range 0.54–6.05 μg/g.
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