Abstract
ObjectiveTo investigate the crude extract of marine actinomycetes with adverse effect locally on the adult Wister albino rats or systematically in the blood circulation. MethodsAcute toxicity, sub acute toxicity, biochemical and histopathological were tested. ResultsIn the results acute toxicity (LD50=2 500 μg/kg bw), sub acute toxicity study (2 500 μg/kg bw) were significant at 5% level of each experimental groups compared to the control group. Biochemical and histopathological study also showed better as compared with control group ConclusionThis crude microbial extract from Streptomyces sp. RSAUT 20 and Streptomyces scabiei (S. scabiei) RSAUK 49 is potential source for novel antimicrobial compounds. The crude extract of Streptomyces sp. RSAUT 20 and S. scabiei RSAUK 49 were tested for in vivo toxicity study.
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