Abstract
The effect of parenteral sodium iodide on hepatic and renal function and acid-base balance was studied in New Zeland white rabbits. Four groups of rabbits were infused intravenously with either 0.15 m NaCl or NaI in different concentrations, 0.03–0.15 m. Renal function as measured by blood-urea-nitrogen and urine protein excretion, hepatic cellular integrity, reflected in the serum activity of glutamic oxaloacetic transaminase, and acid-base balance determined by arterial pH and pCO 2, were the parameters chosen for study. The groups receiving the largest amount of iodide manifested severe hepatic changes, moderate renal changes, and metabolic acidosis. Histologic examination showed marked hepatic vacuolization and necrosis at the highest iodide dose. Renal tubular cells were vacuolated and occasionally necrotic. The genesis of the acidosis is obscure and may be augmented by an inadequate renal compensation for systemic acidosis. It is concluded that, in the rabbit, iodide is toxic to the liver and kidney and produces metabolic acidosis.
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