Toxicity of drug abuse — amphetamine designer drugs (ecstasy): mental effects and consequences of single dose use

Abstract

MDMA (3,4-methylendioxymethamphetamine) is the most commonly used substance within the ‘ecstasy’ group of drugs. MDMA interferes with serotonin and catecholamine transporters in the central nervous system to increase monoamine synaptic levels and thereby mediate the majority of its central nervous effects. These range from wanted effects like euphoria, central nervous stimulation, and feeling of closeness to mild hallucinations, impairment of cognition and co-ordination and further to serious reactions like agitation, disturbed and bizarre behaviour, and possibly psychosis. The full picture of the consequences of these transitory changes is not known. It has been assumed that the risk of being involved in fatalities and accidents during the state of MDMA influence is increased, but this possible risk increase has so far not been determined. Observations of the prevalence of MDMA involvement in cases of reckless driving and the MDMA blood concentrations measured indicate a risk increase comparable to that observed after use of amphetamines.