Abstract
Pũrṇa Cantirotaya Centũram (PCC), a herbometallic formulation of Siddha medicine, consists of mercury, sulphur, and gold, processed with red cotton flower and plantain stem pith juices. To evaluate its safety, acute and 28-day repeated oral toxicity studies were performed following OECD test guidelines 423 and 407, respectively. In acute study, PCC was administered orally at 5, 50, 300, and 2000 mg/kg body weight. Animals were observed for toxic signs for 14 days. Gross pathology was performed at the end of the study. In repeated dose toxicity study, PCC was administered at 2.5, 25, and 50 mg/kg body weight daily for 28 days. Satellite groups (control and high dose) were also maintained to determine the delayed onset toxicity of PCC. In acute toxicity study, no treatment related death or toxic signs were observed. It revealed that the LD50 cut-off value of PCC is between 2000 and 5000 mg/kg body weight. The repeated dose study did not show evidence of any treatment related changes in all observations up to the high dose level, when compared with the control. Histopathological examination revealed no abnormalities except mild hyperplasia of stomach in high dose group. This study provides scientific validation for the safety of PCC.
Highlights
Siddha system of medicine dates back to many centuries
Purn. a Cantirotaya Centuram is prepared with gold, mercury, and sulphur
Weight loss was not observed in any of the groups treated with Purn. a Cantirotaya Centuram (PCC)
Summary
Siddha system of medicine dates back to many centuries. It has been practiced by Tamil vaithiyars (native healers of Tamil Nadu) who taught people an impeccable life style that trails in societies of Tamil Nadu. In Siddha system of medicine, the raw materials like plant, mineral, and animal resources are acquired from the natural surroundings. They have been used extensively for many centuries after thorough evaluation of the drug by traditional way. Siddha medicine describes testing of the end products by some simple checks It insists on the color description, the drug should be fine enough to enter the crevices of finger, and it should float on the water. A Cantirotaya Centuram is prepared with gold, mercury, and sulphur These are the important metals and mineral in Siddha system of medicine, which contributes many therapeutic formulations.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
